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Mitochondria are the main cellular sites for ROS generation [59]

These findings suggest that modulating ferroptosis pathways offers targeted benefits for the coronary microvasculature, addressing a specific component of coronary heart disease that often persists despite successful epicardial coronary intervention

Arch Biochem biophysics

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Firstly, given the evidence that glutathione and glutamate levels in the brain are affected by a risk variant of the gene coding for the glutathione synthesis enzyme, the role of genetic influences should be investigated [22]

We have a constant demand for detoxification, so there needs to be a constant supply of glutathione