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A final alternative to alleviate FcRn-controlled pathological mechanisms could be to alter FcRn in itself, as may be intended with a gene therapy being developed in a collaboration between Beam and Apellis for a one-time dose of gene-editing molecules targeting FcRn [436, 437]

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Purification of CTR/AMYR-DNGs complex in complex with peptide ligands High-titre baculovirus was generated by transfecting recombinant bacmid (CTR, RAMP and DNG s ) or plasmid (G12) into Sf9 cells using the Bac-to-bac baculovirus system (Invitrogen)

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