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In the leuprolide arm of this study, however, there was an initial increase in LH and FSH, and FSH levels never fell as much as in the degarelix arms 36

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The question is whether retatrutide glucagon component provides a specific, direct benefit to liver fat metabolism beyond what weight loss alone would produce

The GIP component enhances insulin sensitivity in fat tissue and may promote beneficial fat metabolism, building on the same principle that makes tirzepatide dosing effective