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A smaller needle (25-27G) is ideal for the actual injection, as it causes less tissue trauma and is more comfortable

Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy

Additionally, the trial will evaluate its effects on atherosclerotic risk factors, such as LDL-c, HbA1c levels, and high-sensitivity C-reactive protein [82]

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Increased intra-abdominal pressure also increases intrathoracic pressure, which is rapidly transmitted up through the venous system, thereby further increasing intracranial pressure (Malbrain and Wilmer, 2007