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It was found that cells harboring IDH1-R132 and IDH2-R172 mutations in patients with acute myeloid leukemia gained the ability to convert -KG to D-2HG [22]

Asian Pacific Journal of Tropical Biomedicine, 3 (4), 253-266

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Such systems allow researchers to examine DSIP-mediated effects on hormone release, neuronal activity, and pathway-level signaling under controlled conditions