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Besides, our research group has previously reported that the MD2-TLR4 complex not only participates in acute inflammatory responses but also recognizes various metabolism-associated molecular patterns (MAMPs) such as palmitic acid, advanced glycation end products, and oxLDL, thereby mediating chronic inflammation in metabolic diseases 46,47,48,49 Thus, we may guess that BDNF attenuates some metabolic diseases through antagonizing TLR4 and then reducing TLR4-driven chronic inflammation

Nicotinamide mononucleotide (NMN) was excluded from the dietary supplement definition by FDA in 2022-2023 and remains in regulatory limbo for new dietary supplement marketing in the US

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Furthermore, PLGA gained food and drug administration (FDA) approval in the 1980s, marking its entry into advanced medical applications 111

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