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Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

Dose escalation followed a stepwise schedule, progressing from 2 mg up to a maximum of 12 mg once weekly over several months, depending on tolerability

Maintenance strategy: Microdosing can serve as a maintenance dose after achieving goal weight

Your body naturally produces GLP-1 in your gut with receptor sites all over your body- brain, bone, blood vessels, heart, and many other places throughout your body

Rather than pushing through exhaustion, evidence-based guidance supports adjusting intensity, protecting sleep, fueling adequately, and maintaining consistent but manageable movement