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Individuals with rare medical conditions that pose a high risk of adverse reactions should avoid these treatments

An important theoretical concern exists: c-Met is overexpressed in multiple human cancers (gastric, lung, colorectal), and chronic c-Met pathway stimulation could potentially influence cancer riskthough this has not been studied longitudinally even in animals

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The mean duration of type 2 diabetes mellitus was 13.3 years, and the mean baseline BMI was 33 kg/m2

It also appears in peripheral organs and body fluids, suggesting systemic regulatory functions beyond the central nervous system

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