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Certain drugs and conditions such as diabetes can cause nerve damage (neuropathy), which manifests with pain, tingling, or numbness in legs and arms [16, 17]

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We noted considerable genetic heterogeneity in our cohort with 16 different pathogenic variants identified of which 11 have not been reported previously (Fig

The first, in the 1970s, was Pickarts discovery work: a factor in human plasma was identified that influenced the survival and growth behavior of cultured liver tissue, and Pickart and Thaler reported the responsible serum tripeptide

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