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Retatrutide is an investigational triple incretin receptor agonist with no current regulatory approval, while tesamorelin is a GHRH analogue licensed in the US for HIV-associated lipodystrophy but unlicensed in the UK

For these patients, microdosing offers a gentler approach to reduce the risk of side effects

Ozempic and Mounjaro are not FDA-approved to treat obesity or for weight loss

Mediation analysis supports a causal relationship between maternal hyperglycemia and placental DNA methylation variations at the leptin gene locus and cord blood leptin levels

But some patients notice something unexpected during their weight loss journey: New or worsening back pain

Ethics declarations Ethics approval and consent to participate The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Independent Institutional Ethics Committee of IRCCS MultiMedica, Milan (protocol code 24/2012(153))