Met has therapeutic potential in treating the diabetic male reproductive system that involves several mechanisms, such as reducing OS and stimulating the adenosine monophosphate (AMP)-activated protein kinase pathway in testicular cells []
The most evidence-based approach is to use a GLP-1 medication for appetite regulation and weight loss, while supporting muscle preservation through adequate protein intake (at least 1.2 g per kg of body weight daily) and regular resistance training
The Mediterranean diet, rich in anti-inflammatory and antioxidant components, is associated with reduced oxidative stress and thyroid inflammation (Osowiecka And Myszkowska-Ryciak 2023)
Many also lead to weight loss but prescribing those only approved by the FDA for type 2 diabetes for weight loss is an off-label use
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Part of the reason is that, while some studies showed strong effects in controlled settings, the evidence was limited (small sample sizes, shortterm)