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Melasma, also known as the mask of pregnancy, can be a source of embarrassment and frustration for those suffering from it, and finding an effective treatment can be challenging

A Phase I safety trial evaluating the administration of synthetic T4 at massive doses ranging from 42mg to 1260mg over 14 days demonstrated excellent tolerability with no severe toxicities or serious adverse events reported in healthy adults

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It works by deactivating activity of the enzyme tyrosinase, which is responsible for pigmentation production

Furthermore, a meta-analysis reported an improvement in AD severity in patients who received a combination of antioxidants, as demonstrated for oral vitamin D and topical vitamin B12, especially in pediatric patients (123)

GHK-Cu injectable was included in that restricted category