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doi: 10.3390/jcm8020217 34 EthertonM.FldyC.SharmaM.TabuchiK.LiuX.ShamlooM.et al

(28, 29) Irritable Bowel Disease (IBD) Another major side effect of Accutane is irritable bowel disease, or IBD

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The key molecular pathway identified involves the activation of the general control nonderepressible 2 (GCN2) kinase, leading to the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) and the upregulation of ATF4