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Large-scale trials demonstrate that semaglutide may modestly reduce systolic blood pressure by approximately 25 mmHg, likely due to weight loss and improved metabolic health

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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Bugajski AJ, et al

Patients on semaglutide, liraglutide, or tirzepatide should be told that excessive daytime sleepiness is a possible side effect, with an absolute incidence of roughly 0.40.7 percentage points above baseline at 1 to 5 years

Patients with a personal or family history of medullary thyroid carcinoma (MTC) or patients with multiple endocrine neoplasia syndrome type 2, the GLP-1 agonist are CONTRAINDICATED