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However, recurrent bouts of such inflammation and the toxic milieu that ensues, are thought to produce cumulative damage to myelin, oligodendrocytes and neurons, leading to progressive degeneration, atrophy and increasing disability, exacerbated by failure of myelin repair

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Our study may prove that these endpoints are not suitable for irritancy testing of copper compounds in a monolayer HaCaT assay

10.1016/j.neulet.2014.09.039 13 BejE.CesareP.dAngeloM.VolpeA