Which injection site causes less bruisingstomach or thigh
10.1038/s41568-019-0135-7 Nat Rev Cancer
Hypoglycemic Drugs Insulin Secretagogues Sulfonylureas 1st Generation Sulfonylureas: Tolbutamide & Chlorpropamide RARELY PRESCRIBED (lower potency, greater toxicity) Trade Names: Tolbutamide (Orinase , Oramide ) Chlorpropamide (Diabinese ) Drug Class: oral hypoglycemic, sulfonylurea, first generation The use of 1st generation drugs has been replaced by newer generation sulfonylureas (mentioned here for historical purpose only) Keywords 2nd Generation Sulfonylureas: Glimepiride, Glipizide & Glyburide Fewer drug interactions, & side effects, more commonly prescribed Drugs & Trade Names: Glimepiride (Amaryl ) Glipizide (Glucotrol , Glucotrol XL ) Glyburide (DiaBeta , Micronase ) Drug Class: oral hypoglycemic, sulfonylurea, second generation Mechanism of Action: blocks ATP-regulated K channels causing depolarization that results in Ca influx and enhanced insulin release from pancreatic -cells (see Figure 1 in Beta Cell Pharmacology)
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All told, is this a small price to pay for avoiding needles
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Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention