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Some probiotic strains appear to support the same hormonal pathway that semaglutide activates directly

However, the protective effect was strongest in patients with obesity and absent in non-obese patients, strongly suggesting that benefits are heavily confounded by weight loss and metabolic improvement rather than direct gut anti-inflammation (101)

Since digestive side effects are already common with this medication, mixing in similar supplements may increase nausea or lead to unexpected blood sugar swings

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