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Receptor activation initiates intracellular pathways including PI3K/Akt and MAPK signalling cascades, which regulate cellular proliferation, protein synthesis, metabolic activity, and apoptosis resistance

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Allopurinol and febuxostat: to decrease production of uric acid Probenecid: to increase the excretion of uric acid Pegloticase: to increase the breakdown of uric acid Standard medications in preventing gout attacks i

The inflammatory component often improves before structural healing becomes apparent