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Similarly, OW semaglutide 0.5 mg and 1 mg were projected to be cost-effective versus empagliflozin 10 mg and 25 mg (an SGLT2i) for the treatment of patients with T2D with inadequate glycaemic control in Spain on the basis of a network meta-analysis of clinical data for the two drugs [62]

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[8] One drink per day for women or two per day for men represents the outer boundary of what most physicians consider acceptable during active weight-loss therapy, not a recommended target

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The transient nature of blood pressure changes, combined with the on-demand dosing strategy, mitigates concerns about sustained cardiovascular effects during long-term use