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Regarding the effect on the expression of TLRs of APCs, this may contribute to an imbalance in the Th17/Treg cell ratio and this local immune response could lead to systemic autoimmunity (Horta-Baas et al., 2017)

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However, the absolute risk difference was small, and the clinical significance of this finding remains uncertain

Yes, they absolutely do

Vital et al., 2017)