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Therefore, several classes of drugs, such as alpha-glucosidase inhibitors (AGI), amylinomimetics, biguanides, bile acid sequestrants, dopaminergic antagonists, DPP4 inhibitors (DPP4i), insulin and insulin secretagogues (IS), sulfonylureas, meglitinides, sodium-glucose cotransporter-2 inhibitor (SGLT2i), and thiazolidinediones (TZDs), including the glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been made available for the management of T2DM (Tahrani et al., 2016

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For researchers who have desensitized to dual agonist therapy, the addition of the glucagon receptor pathway provides genuinely novel stimulation