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It is also very necessary to identify if TMAO contributes to chondrocytes injury through modulating the classical pathways of ferroptosis such as ACSL4/GPX4 or other specific pathways, such as those of iron-related proteins, lipid peroxidation products, and other sensitivities to mechanical stimulation

doi: 10.18632/aging.100450 45 HamzeM.BrierC.BuhlerE.ZhangJ.MedinaI.PorcherC

The participants consuming the intervention did not alter their common diet or perform extra physical activity intended to alter metabolic parameters

Conclusions In general, our study indicated that chronic ethanol exposure may cause exacerbated continuously deteriorating cognitive impairment and neuroinflammatory damage in APP/PS1 mice compared to WT mice

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