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The gut-brain axis is increasingly highlighted as an important pathway connecting gut microbiota and its metabolites with central regulation of metabolism

Clin Cosmet Investig Dermatol 7:267274

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It seems very unlikely that the glucagon released by GIPR activation counteracts the incretin effect, as this would result in a counterproductive postprandial response that would not promote metabolic homeostasis in the individual

If given IV, it must be injected slowly (often over at least 5 minutes or diluted in a larger volume bag and infused)

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