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In a similar study in rabbits in which the same doses were administered from GD 6 through 18, no effects on embryo-fetal development were observed at approximately 0.1 times (phentermine) and 1 time (topiramate) clinical exposures at the MRHD based on AUC

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Ginsenoside rg1 regulates liver lipid factor metabolism in nafld model rats

Clinicians should remain vigilant for class-specific adverse effects, including rare but serious complications such as euglycemic diabetic ketoacidosis with SGLT2is and gallbladder disease or pancreatitis with GLP-1RAs [11, 15]

Conversely it says those with type 2 diabetes, prediabetes or cardiovascular risk factors may find GLP-1's dual benefits a better fit