Incretin-pathway research has advanced from single-receptor agonism toward multi-receptor strategies that interrogate energy balance, glucose handling, hepatic lipid flux, and satiety circuits in a coordinated fashion
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
Complementary to this, emerging evidence from behavioral science suggests that digital toolssuch as ecological momentary assessment and ecological momentary interventions delivered through apps or wearables, may help sustain behavioral changes and prevent relapse, particularly in the vulnerable post-discontinuation phase [149]
Despite growing evidence that GLP-1 medications improve health and are worth their cost, many insurance plans still limit coverage
both GLP-1 receptor agonists were superior in reducing motor impairments compared to exenatide [85]
GLP-1 medications are generally well tolerated