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Reliably raises growth hormone levels 30 to 60 minutes after injection, while still following the body's natural pattern of releasing it in bursts rather than a constant stream

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Common adverse effects include gastrointestinal symptoms such as nausea (12-29% of patients), diarrhea (12-16%), vomiting (6-9%), and constipation (6-11%), with rates varying by dose

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Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)

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