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USA 104 , 68286833 (2007)

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Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

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12 For patients with an eGFR between 30 50 mL/minute/1.73m 2 , the dose should be reduced to 1000 mg, twice daily