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In the acute window (024 h) the priority is to contain ROS spikes (e.g., ischemiareperfusion, SIRS) by attenuating the source (NOX/mitochondrial bursts), buffering at the compartment of origin (mitochondria, ER, endothelium) and controlling free metals that license Fenton chemistry

Hydrate (little and often) Aim for regular sips throughout the day

Each product expanded the market, sharpened the clinical use case, improved the patient fit, and made the next launch more legible to physicians, payers, and patients

Adequate hydration requires 8-10 glasses of water daily, with an additional 8 ounces for every gram of added fiber to prevent worsening constipation

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