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Non-hormonal mechanism of action, reducing systemic side effect risks

[DOI] [PubMed] [Google Scholar] 3.Lamb J

GPX3 can suppress the expression of HIF-1 by regulating ROS, affecting tumor cell energy metabolism, and inhibiting the growth of melanoma cells (51)

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Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes