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NICE guidance requires GLP-1 treatment to be part of a multicomponent weight management programme within specialist NHS services

Oral peptide products are widely sold online outside any medical oversight, and quality in that market is inconsistent

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NSAIDs like ibuprofen inhibit cyclooxygenase enzymes, which cuts the protective prostaglandins that shield the gastric lining, while semaglutide independently delays gastric emptying and raises nausea risk

Due to the lack of sub-analyses by dose or T2DM status, only an average summary effect could be reported

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