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Metabolic effects of very-low calorie diet, semaglutide, or combination in individuals with type 2 diabetes mellitus

Speiser PW, Rudolf MC, Anhalt H, Camacho-Hubner C, Chiarelli F, Eliakim A, Freemark M, Gruters A, Hershkovitz E, Iughetti L, Krude H, Latzer Y, Lustig RH , Pescovitz OH, Pinhas-Hamiel O, Rogol AD, Shalitin S, Sultan C, Stein D, Vardi P, Werther GA, Zadik Z, Zuckerman-Levin N, Hochberg Z, Obesity Consensus Working Group

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As exposure progresses, the expression of the insulin synthesis transcription factors such as PDX1 and MAFA decreases, disrupting the insulin synthesis