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This instability is attributed to glucagons insolubility in pH neutral aqueous solutions, its temperature dependency, the tendency to form potentially cytotoxic fibrils, and its susceptibility to degradative oxidation and deamidation [132], [29], [60], [71]

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the latter are subjected to study in animal models for the elucidation of mechanisms leading to development and progression

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The total weight change on the scale was modest compared to semaglutide