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MEK162 for Patients With Advanced Melanoma Harbouring NRAS or Val600 BRAF Mutations: A non-Randomised, Open-Label Phase 2 Study

Saturated fatty acid activates T cell inflammation through a nicotinamide nucleotide transhydrogenase (NNT)-dependent mechanism

The pathogenesis involves a combination of cell-mediated and humoral immune responses, initiated in genetically predisposed individuals upon exposure to environmental triggers

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Central nervous system GLP-1 receptors are distributed throughout brain regions implicated in depression, including the hippocampus, prefrontal cortex, and nucleus accumbens