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Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

For MS analysis, a positive ion mode (SIM) was used to monitor the m/z of dihexa at 527nm (dihexa with the addition of a sodium adduct) and the m/z of Nle-YI-(6) aminohexanoic amide and Nle 1 - AnglV (internal standards) at 513 and 541 , respectively (both with sodium adducts)

In infants, untreated deficiency may result in neurological impairment and anemia

Lower doses are still highly effective

During the process it was painless and calming energy