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AOD-9604 is peripherally acting

doi: 10.1093/nutrit/nuad082

Conflicts of interest Both authors declare that there is no conflict of interest

Moreover, in humans with obesity, SCFAs are significantly increased in feces [8] while in genetically obese mice there was an increased capacity to extract SCFAs from the diet providing additional energy to the host (about 10% of total energy from the diet) as compared to lean littermates [9]

Treatment discontinuation due to gastrointestinal events occurred in a minority of patients, and overall, serious adverse events were similar to those with the placebo

Synthesizing it correctly requires sophisticated equipment and quality control