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Neutrophils activate Toll-like receptors and CD14+ T cells, promoting the release of inflammatory mediators [IL-1, TNF-, nitric oxide (NO) and ROS] (97,98)

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PK data indicate a large volume of distribution, immature hepatic metabolism via CYP2B6 and CYP3A4, and a prolonged half-life in preterm infants (167, 169172)

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