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in healthy human volunteers, the eyes open state had correlated higher FCD, ALFF, whole-brain correlation, and glucose uptake than the eyes closed state [27] and awake mice had higher FCD [59], blood flow, and oxygen metabolism [60] than mice under dexmedetomidine anesthesia

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Thats right in line with the results doctors are seeing from the injectable Wegovy

Semaglutide GLP-1 , particularly in its Ozempic form, was originally developed to manage type 2 diabetes but has proven effective for weight loss as well