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Methods Animals Twelve-weeks-old male C57BL/6 mice were housed in the animal facility of the Department of Pharmacology and Pharmacotherapy, University of Pcs, in a room with controlled temperature and humidity, in standard polycarbonate cages (365 mm x 207 mm x 144 mm) at 12-hour light-dark cycles (lights on: 6 a.m.)

The remaining 3 studies, scored eight and nine, indicating high-quality studies with low risk of bias (Table 5)

For Systemic Application (via Subcutaneous Injection): A standard protocol for general systemic research often starts at the lower end of this spectrum

In cases where hyperpigmentation occurs, there are several effective treatments and management strategies: 1

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S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen-glucose deprivation and reoxygenation by upregulating GAB1 expression