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141 In an uncontrolled trial in 690 men diagnosed with infertility and found to have low sperm motility and high sperm DNA fragmentation, 14 weeks of supplementation with a combination of 400 IU vitamin E plus 200 mcg selenium daily improved sperm motility, morphology, or both, and resulted in a 10.8% pregnancy rate after 14 weeks

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MODE 3 Time-Course Metabolic Perturbation Profiling Samples collected at multiple time points after compound addition reveal the temporal sequence of metabolic pathway involvement distinguishing primary metabolic effects (rapid, often within 14 hours) from secondary and adaptive responses

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