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Clinical Evidence: Semaglutide's Proven Cardiovascular Outcomes The SUSTAIN-6 trial (2016) was the first major study to confirm semaglutide's heart-protective effects in patients with type 2 diabetes and established cardiovascular disease

70,71 Additionally, the exploration of GLP-1R positive allosteric modulators (PAMs) offers a new regulatory approach that could enhance the therapeutic profile of small-molecule GLP-1R agonists

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GLP-1s are approved for weight loss in adults who have a body mass index of 30 or higher, and those who are overweight with a body mass index of 27 or higher with at least one weight-related health condition such as high blood pressure, high cholesterol and type 2 diabetes