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PCR showed that Exendin-4 down-regulated the expression of senescence associated gene (p16, p21, p53) and up-regulated the expression of bone-related gene

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Stability declines above 77F, and degradation accelerates sharply above 86F

5.3.3 Bile acids High-fat diet (HFD) reshapes microbiota-dependent bile acid metabolism and promotes the accumulation of secondary bile acids such as deoxycholic acid (DCA) (152)