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Trk [email protected] This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Likewise, tuning glutaminolysiswhich supports anaplerosis and can fuel NADPH production via malic enzyme and IDH1/2modulates mitochondrial substrate pressure, ROS formation, and effector functions (Ju et al