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Ubiquitin-specific protease 18 (USP18) inhibitions lead to activation of nuclear factor kB (NF-kB) signaling, and augmented expression of pro-inflammatory cytokines with elevated inflammatory biomarkers is the possible way by which ATV/r increases the serum level of hsCRP levels ( Limitations and strength Concerning strength, this was the first study in Ethiopia that attempted to assess the effects of DTG and ATV/r-based regimens on serum uric acid and high-sensitivity C-reactive protein levels among people living with HIV, hence ultimately adding to the limited data

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