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It is estimated that 0.7% of Australians are currently accessing semaglutide, with predictions that almost one in 10 Australians will be on a GLP-1RA by the year 2030

Acknowledgements Not applicable Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB)

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Despite their potential to potentiate SDF-1 and thereby exacerbate the vascular complications of type 2 diabetes, DPP-4 inhibitors have emerged as a popular choice for the treatment of the disease because of their ease of use, tolerability and ability to produce predictable and sustained lowering of blood glucose

The most commonly reported adverse events were nausea and vomiting, which were generally transient and dose-dependent

Wadden and colleagues assessed changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and suicidal ideation or behaviors using the Columbia Suicide Severity Rating Scale in participants with overweight or obesity using semaglutide 2.4 mg or placebo