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Human randomized trials show no clear excess of thyroid cancer, and large observational studies are mixed, with one finding a small relative increase and a larger one finding no increased risk

Ideal candidates are those who are near their goal weight, have good skin quality, and no unresolved medical or skin conditions

Alternative diabetes or weight management therapies should be considered in consultation with specialist services

In the STEP 1 trial, adults with obesity or overweight (without diabetes) who took weekly semaglutide lost about 15% of their body weight on average over 68 weeks, alongside lifestyle support, compared with about 2.4% in the placebo group

doi:10.1016/S2213-8587(22)00187-5 91