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Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
Common injection sites used in trials include: The abdomen (at least 5 cm away from the navel) The upper thigh The upper arm (outer aspect) Rotating injection sites with each weekly dose is recommended to reduce the risk of localised skin reactions such as bruising or injection site discomfort
GLP-1 stands for glucagon-like peptide-1
32,107,234 Interestingly, in contrast to this, a recent study concluded that central and peripheral GLP-1 systems suppress eating via independent gut-brain circuits in mice
Interestingly, one study found that GLP-1R knockout mice were protected from high-fat diet-induced insulin resistance and had enhanced insulin-stimulated skeletal muscle glucose uptake, and these mice also exhibited enhanced action of insulin on hepatocytes as well as decreased hepatic and skeletal muscle triglyceride accumulation
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