step 1 semaglutide 2.4 mg weight loss percent 2·4 once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial Alternative dosing regimens of GLP-1

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Wang Y, Wu Y, Wang Y, Xu H, Mei X, Yu D, et al

When considered against active comparators, semaglutide also increased the likelihood of participants losing 5% fasting body weight, with ORs ranging from 1.29 (95% CI 0.70, 2.13 [T2DM]) to 2.17 (95% CI 1.44, 3.27 [NGT]) with liraglutide 3.0 mg and from 6.09 (95% CI 2.86, 11.95 [total population]) to 7.75 (95% CI 5.29, 11.37 [non-T2DM]) with orlistat 120 mg three times daily (TID)