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However, patients should not self-treat severe or persistent constipation without medical advice, especially if they develop pain, bloating, vomiting, inability to pass stool or gas, or rectal bleeding

There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)

Consistent dosing is one of the simplest ways to support reliable results

Aim for 2.5-3 liters of water daily during active episodes

M., Govers, R

People with diabetes also need medication review because insulin, sulfonylureas, and appetite changes can interact in clinically important ways