GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
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Non-Covered Uses of B12 Injections Medicare does not cover B12 injections intended for non-medically necessary uses, such as strengthening tendons or ligaments
Previous bariatric surgery Patients with any history of gastric bypass, sleeve gastrectomy, or other bariatric procedures require lifelong b12 monitoring and supplementation
Similarly, individuals with certain types of cancer, especially those related to hormones, should consult with their healthcare provider before considering lipotropic injections, as some components might influence hormone levels
NAD+ and longevity stacks Given that 5-amino-1mq works by preserving NAD+ levels, combining it with direct NAD+ precursors like NMN or NR makes mechanistic sense