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The steps are simple, but each one has a reason behind it

The peptides occupy the extracellular domain and the orthosteric pocket, whereas the small molecules wedge into the transmembrane region around Trp33

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36,61 However, exenatide ER is encapsulated in microspheres of medical-grade poly-(D,L-lactide-co-glycolide), which ensures the gradual and extended release of the drug (Figure 2B)